Can the same amino acid sequences could fold differently?

Different protein sequences can give rise to highly similar folds through different stabilizing interactions. Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, California 94305.

Can two different proteins be composed of the same number and type of amino acids?

Each type of protein has a unique sequence of amino acids, exactly the same from one molecule to the next. Many thousands of different proteins are known, each with its own particular amino acid sequence.

Can the same amino acid have different properties?

In addition to the amino and carboxyl groups, amino acids have a side chain or R group attached to the α-carbon. Each amino acid has unique characteristics arising from the size, shape, solubility, and ionization properties of its R group.

What causes amino acids to fold in different patterns?

Hydrogen bonding between amino groups and carboxyl groups in neighboring regions of the protein chain sometimes causes certain patterns of folding to occur. Folded proteins are stabilized by thousands of noncovalent bonds between amino acids.

Why are two proteins with the same amino acid composition do not have the same primary structure?

No two proteins with different amino acid sequences (primary structure) have identical overall structure. The unique amino acid sequence of a protein is reflected in its unique folded structure. This structure, in turn, determines the protein’s function.

Can proteins with different amino acid sequences have similar structures?

It is possible and known in certain cases. The sequence of amino acids in a protein defines the structure of the protein, however different amino acid sequence may also result in similar structure or conformation.

What part of the amino acid varies from one amino acid to another?

Each amino acid shares a common set of atoms that make up the amino acid backbone. Attached to the central carbon atom (the alpha carbon) is an atom or group of atoms that varies among the amino acids, making them all different. This group is sometimes called the R group or amino acid sidechain.

Why do proteins have different shapes if they are all composed of amino acids?

Each protein has its own unique sequence of amino acids and the interactions between these amino acids create a specify shape. This shape determines the protein’s function, from digesting protein in the stomach to carrying oxygen in the blood.

Why do different proteins contain a different number and a different sequence of amino acids?

Proteins different in length and compositions because the sequence that makes them (their gene) is composed of different nucleotides. Different genes have different nucleotide sequences, and hence different proteins are produced.

How can two proteins with exactly the same number and type of amino acids have different primary structures?

The order of the amino acids (primary structure) in the two proteins may be different. This can result in ionic, hydrogen and disulphide bonds to form in different locations in each protein. Such differences may cause variations in the three dimensional structures of the proteins (tertiary structure).

Can two proteins have the same number and type of amino acids?

Two proteins have the same number and type of amino acids but different tertiary structures. Explain why. The order of the amino acids (primary structure) in the two proteins may be different.

How do amino acids affect the structure of a protein?

The order of the amino acids (primary structure) in the two proteins may be different. This can result in ionic, hydrogen and disulphide bonds to form in different locations in each protein. Such differences may cause variations in the three dimensional structures of the proteins (tertiary structure).

What determines the three-dimensional architecture of a protein?

The sequence of amino acids in a protein determines its folded structure The specific order of amino acids in a protein is known as its primary structure. It is this sequence that determines the three-dimensional architecture of a protein.

What is the most important factor that affects protein folding?

Therefore, an important factor governing the folding of any protein is the distribution of its polar and nonpolar amino acids.