How many mg of metoprolol is fatal?

How many mg of metoprolol is fatal?

The two fatal overdose levels were deter- mined to be 50 mg/L in blood and 120 mg/kg in liver (6), and 56 mg/L in blood, 42 mg/L in vitreous humor, 276 mg/L in bile, and 260 mg/kg in liver (7). Several analytical procedures for the determination of metoprolol in biological specimens have been reported (8-13).

Can too much metoprolol cause death?

A death due to deliberate ingestion of metoprolol is described, including the case history, postmortem toxicologic findings, and identification and quantitation of the drug by high pressure liquid chromatography and gas chromatography/mass spectrometry.

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What are the side effects of taking too much high blood pressure medicine?

High Blood Pressure Medication Side Effects to Watch For

  • Asthma symptoms or a hacking cough.
  • Diarrhea, severe heartburn, or persistent nausea.
  • Erectile dysfunction (impotence)
  • Extreme, persistent drowsiness, weakness or fainting.
  • Falling due to dizziness when standing up.
  • Frequent headaches.
  • Heart palpitations.

What happens if you take your blood pressure medication twice by mistake?

Taking a double dose of any medicine is also okay – but it is not a good idea. The main risk is that you might get side effects for a few hours due to the short time when you have higher drug levels. It is better to get a pill box. Then you can see each day whether or not you have taken your meds.

Is 200 mg of metoprolol too much?

Adults—At first, 25 milligrams (mg) once a day for 2 weeks. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day.

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How long does metoprolol stay in your system?

Metoprolol has a half-life of between 3 and 7 hours. This means that after 3 to 7 hours, half of a dose of the drug has been eliminated from your body.

Is 200 mg of metoprolol a lot?

How much metoprolol can you take in a day?

Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day.

What are the signs of an overdose of metoprolol?

Investigations. Poisoning due to an overdose of metoprolol may lead to severe hypotension, sinus bradycardia, atrioventricular block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impairment of consciousness, coma, nausea, vomiting, cyanosis, hypoglycaemia and, occasionally, hyperkalaemia.

What are the symptoms of a drug overdose?

Central nervous system (CNS) depressants: shallow breathing,weak pulse,clammy skin,coma,death from respiratory arrest

  • Hallucinogens: psychotic features,agitation,delirium
  • Inhalants: marked CNS depression,loss of consciousness,stupor or coma,arrhythmia,sudden death
  • What are symptoms of SSRI overdose?

    Signs and symptoms include: Agitation or restlessness. Confusion. Rapid heart rate and high blood pressure. Dilated pupils. Loss of muscle coordination or twitching muscles. Muscle rigidity. Heavy sweating.

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