What forms when aspirin reacts with NaOH?

It is a benzoic acid, substituted in the ortho position with an acylated alcohol (actually a phenol) function. Thus, there are two reactions that can occur between aspirin and NaOH: the faster will be deprotonation of the acid function, so you’ll get sodium acetylsalicylate.

Why NaOH can be used to titrate aspirin?

To determine the amount of aspirin (acetylsalicylic acid) in a sample, the precise volume and concentration of the NaOH, and the overall reaction, must be known. The NaOH serves as a secondary standard, because its concentration can change over time.

What does aspirin react with?

Some products that may interact with this drug include: mifepristone, acetazolamide, “blood thinners” (such as warfarin, heparin), corticosteroids (such as prednisone), dichlorphenamide, methotrexate, valproic acid, herbal medications (such as ginkgo biloba).

How many moles of NaOH reacts with aspirin?

one mole
The aspirin/NaOH acid-base reaction consumes one mole of hydroxide per mole of aspirin.

What is the reason for boiling the NaOH and aspirin mixture?

This involves reacting the aspirin solution with a measured amount of sodium hydroxide; an amount that will exceed the amount of aspirin present. Because the hydrolysis reaction occurs at a very low rate at room temperature it will be heated to increase the reaction rate.

Does salicylic acid dissolve in NaOH?

1) Aromatic acids like benzoic acid and salicylic acid are NOT soluble in water. But they are soluble in 5\% NaOH, and 5\% NaHCO3.

How does acetic acid remove aspirin?

The excess acetic acid will be quenched with the addition of water. The aspirin product is not very soluble in water so the aspirin product will precipitate when water is added. The synthesis reaction of aspirin is shown below: Since acetic acid is very soluble in water, it is easily separated from the aspirin product.

What is aspirin chemistry?

One of the best known aromatic acetates is acetylsalicylic acid, or aspirin, which is prepared by the esterification of the phenolic hydroxyl group of salicylic acid. Aspirin possesses a number of properties that make it the most often recommended drug. It is an analgesic, effective in pain relief.

Where does aspirin react?

Aspirin binds to and acetylates serine (an amino acid used by the body to make proteins) residues in the active site of cyclooxygenase enzymes, leading to reduced production of prostaglandin. This in turn mediates aspirin’s effect of reduced inflammation and pain in affected tissues.

Is aspirin soluble in NaOH?

Aspirin would be slightly soluble in NaOH because the carboxylic acid group would be deprotonated making it negatively charged.

How do you find the concentration of aspirin through NaOH titration?

Starts here4:25Chemistry Lab Skills: Aspirin Titration – YouTubeYouTube

What happens when aspirin reacts with water?

Aspirin is a pain reliever and fever reducer, but if it’s allowed to react with water then it can undergo hydrolysis, forming salicylic acid and acetic acid, which is no longer effective. This reaction can occur under acidic or basic conditions.

Is NaOH and aspirin an acid or base?

The aspirin/NaOH acid-base reaction consumes one mole of hydroxide per mole of aspirin. Click to see full answer. Just so, how does aspirin react with NaOH? This is an acid-base reaction in which the acetylsalicylic acid reacts with the base sodium hydroxide to produce the salt sodium acetylsalicylate and water (acid + base → salt + water).

What happens when NaOH reacts with salicylic acid?

The molar mass of NaOH is approximately 0.290 times that of salicylic acid; thus, 10.00 grams of salicylic acid would be reacted with 2.90 grams of NaOH. This is because NaOH has a formula weight of 29.0\% that of salicylic acid. Dissolve the NaOH in as little distilled water as required to solubilize it completely.

How do you titrate sodium hydroxide and aspirin?

This is achieved by using the method of back titration. In this, the amount of moles in the sodium hydroxide solution after it has been reacted with the aspirin is found using titration and then compared with the amount of moles it had without the aspirin being added.

Why does NaOH not dissolve in water?

This is because NaOH has a formula weight of 29.0\% that of salicylic acid. Dissolve the NaOH in as little distilled water as required to solubilize it completely. Beside above, what does aspirin dissolve in?