Table of Contents
What is acetanilide used for?
acetanilide, synthetic organic compound introduced in therapy in 1886 as a fever-reducing drug. Its effectiveness in relieving pain was discovered soon thereafter, and it was used as an alternative to aspirin for many years in treating such common complaints as headache, menstrual cramps, and rheumatism.
Where does acetanilide come from?
In terms of how acetanilide is synthesized, it’s most commonly made by reacting aniline with either acetyl chloride or acetic anhydride. Although both methods work equally well, the preparation from acetic anhydride tends to be preferred due to the corrosiveness and toxicity of acetyl chloride.
What is acetanilide made of?
Acetanilide is produced from aniline using Acetic acid. The shiny, leaflet crystals are stable in air. Acetanilide was used in the 19th century to treat fever and headaches but was discontinued because of toxic side effects.
Why is acetanilide not used as a drug?
Unfortunately, Acetanilide exhibited an unacceptable profile of toxic effects, the most alarming being cyanosis due to methemoglobinemia. Acetanilide is no longer used as a drug in its own right, although its primary metabolite, paracetamol, has been widely succesful.
Is acetanilide a paracetamol?
Brodie and Axelrod’s two publications on acetanilide in 1948 in the same journal convinced the medical and scientific community that paracetamol, a major metabolite of acetanilide, was responsible for the antipyretic and analgesic action of acetanilide.
Is acetanilide an alcohol?
Acetanilide is an odourless solid chemical of leaf or flake-like appearance….Acetanilide.
| Names | |
|---|---|
| Melting point | 113–115 °C (235–239 °F; 386–388 K) |
| Boiling point | 304 °C (579 °F; 577 K) |
| Solubility in water | <0.56 g/100 mL (25 °C) |
| Solubility | Soluble in ethanol, diethyl ether, acetone, benzene |
What is the biotransformation of acetanilide?
Acetanilide like phenylbutazone is paraoxidized by the liver endoplasmic reticulum as a primary biotransformation step. Plasma clearance values and half lives of acetanilide were measured in this group of patients and compared with those of a group of 30 healthy volunteer controls.
Is Acetanilide a paracetamol?
Is Acetanilide an alcohol?
What metabolite of acetanilide has replaced it as an over the counter pain killing drug What is the brand name of this metabolite?
Although acetanilide is no longer used as a pharmaceutical drug in its own right, the success of its metabolite – paracetamol (a.k.a. acetaminophen) – is well known as a safer alternative (9).
Is acetanilide a carcinogen?
OSHA: No component of this product present at levels greater than or equal to 0.1\% is identified as a carcinogen or potential carcinogen by OSHA. Inhalation – May cause respiratory irritation. Inhalation May be harmful if inhaled. Eyes Causes eye irritation.
What metabolite of acetanilide has replaced it as an over the counter pain killing drug?
Thus, Acetanilide has largely been replaced by less toxic drugs, in particular acetaminophen (i.e. paracetamol), which is a metabolite of Acetanilide and whose use Axelrod and Brodie suggested in the same study (8).
What are the health hazards of acetanilide?
SYMPTOMS: Symptoms of exposure to this compound may include contact dermatitis and eczematous skin eruptions; anemia and cyanosis. ACUTE/CHRONIC HAZARDS: This compound is an irritant. It emits toxic fumes when heated to decomposition.
What are the functional groups of acetanilide?
A: The functions groups present in acetanilides are the following, arene and amide. These groups are considered polar. Since water is also polar, acetanilide reacts really well with water molecules. Making water a really good recrystallization solvent for acetanilide.
What does acetanilide mean?
acetanilide in British. (ˌæsɪˈtænɪˌlaɪd ) or acetanilid (ˌæsɪˈtænɪlɪd ) noun. a white crystalline powder used in the manufacture of dyes and rubber, as an analgesic in medicine, and as a precursor in penicillin manufacture.
Is acetanilide an amide?
Acetanilide is an aromatic amide with the molecular formula C6H5NH(COCH3). It is an odorless, white to gray flake solid or a crystalline powder at room temperature. Acetanilide is soluble in few solvents including hot water, alcohol, ether, chloroform, acetone , glycerol , and benzene .