What is Claisen condensation reaction write its mechanism?

The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base, resulting in a β-keto ester or a β-diketone. It is named after Rainer Ludwig Claisen, who first published his work on the reaction in 1887.

What is Claisen condensation with example?

The Claisen condensation is the ester analogue of the Aldol condensation. The reaction involves an ester enolate reacting with another molecule of the ester. A simple example of a Claisen condensation is the reaction of ethyl ethanoate which is shown below in two representations.

What is the product of Claisen condensation reaction?

The product of a Claisen condensation is a beta-keto ester, which is a significantly stronger acid (pKa = 11) than either alcohols (pKa = 16-17) or esters (pKa = 25).

What intermediate is in Claisen condensation?

In the ‘main’ part of the Claisen condensation mechanism, the α-carbon of a second acetyl CoA is deprotonated (step 1), forming a nucleophilic enolate. The enolate carbon attacks the electrophilic thioester carbon, forming a tetrahedral intermediate (step 2) which collapses to expel the cysteine thiol (step 3).

What is aldol and Claisen condensation explain the mechanism of it?

Aldol condensations are important in organic synthesis, because they provide a good way to form carbon–carbon bonds. The reaction between an aldehyde or ketone having an α-hydrogen with an aromatic carbonyl compound lacking an α-hydrogen is called the Claisen–Schmidt condensation.

Which intermediate is involved in Claisen condensation?

What is the Claisen Schmidt reaction?

The Claisen-Schmidt reaction (crossed-aldol reaction) is a condensation reaction of aldehydes and carbonyl compounds leading to β-hydroxycarbonyl compounds and it has played an important role in synthetic organic chemistry [1,2,3,4,5,6].

Which catalyst is used in Claisen condensation?

Although many Claisen condensations are carried out with a full equivalent of the alkoxide base, an effective alternative procedure, used in reaction #5, uses sodium hydride (NaH) together with a catalytic amount of alcohol.

Which intermediate is involved in Claisen and condensation?

What is claisen Schmidt condensation reaction?

The condensation of an aromatic aldehyde with an aliphatic aldehyde or ketone in the presence of a base or an acid to form an α,β-unsaturated aldehyde or ketone with high chemoselectivity is generally known as Claisen–Schmidt condensation.

What is the Claisen Schmidt reaction used for?

What is Claisen condensation?

What is Claisen Condensation? The Claisen condensation reaction is an organic coupling reaction that results in the formation of a C-C bond between either a single ester and one carbonyl compound or between two esters. The reaction proceeds when a strong base is present and the product of the reaction is a beta-keto ester or a beta-diketone.

What happens when naoc2h5 reacts with alpha carbon?

What happens is that NaOC2H5 takes H from alpha carbon and that’s how it initiates many different reactions such as Claisen condensation, Dieckmann condensation, Alkylation, Malonic ester synthesis….etc.

How is the Claisen condensation reaction closely related to the aldol reaction?

The Claisen condensation reaction is closely related to the aldol condensation reaction since both of them are organic condensation reactions involve the addition of enolates to organic compounds.

What is the second part of a Claisen reaction?

The second part of the reaction is an acidic workup to make sure a neutral product is obtained. For a given Claisen reaction, there is essentially one suitable base that can be used. And that is the alkoxide ion having the same alkyl group as the reacting esters.