What is periodic paralysis?

Periodic paralysis (PP) is a rare genetic disorder. It causes sudden attacks of short-term muscle weakness, stiffness, or paralysis. These attacks may affect the whole body or just 1 or 2 limbs. There are several different forms of PP. They all involve defects in ion channels.

What is Hyperkalemic periodic paralysis caused by?

Hyperkalemic periodic paralysis is caused by mutations in the SCN4A gene and is inherited in an autosomal dominant manner. Diagnosis is based on clinical symptoms including the increase of blood potassium level during an episode, but normal levels of blood potassium level in between episodes.

Is Hyperkalemic periodic paralysis life threatening?

Some people with the disease might experience only a few mild attacks in their lifetime. But the most profound attacks can cause nearly full-blown paralysis, and permanent muscle damage may occur.

Is Hypokalemic periodic paralysis dangerous?

Gamstorp disease, also known as hyperkalemic periodic paralysis, is a rare genetic condition that causes episodes of muscle weakness or temporary… Sleep paralysis is a temporary loss of muscle function while you’re sleeping that can be frightening but is harmless.

Who gets periodic paralysis?

Who gets Primary Periodic Paralysis? It affects about 5,000 to 6,000 individuals in the US (~3 in every 200,000 people), both male and female. Attacks usually appear in later childhood, before a person reaches the age of 20. However, some people begin having attacks in early childhood.

Can periodic paralysis cure?

For ATS, potassium supplements can prevent attacks of paralysis. You may need to take heart medicines such as beta-blockers to control an abnormal heart rhythm. Since TPP is caused by an overactive thyroid gland, your doctor will usually treat it by treating the thyroid condition.

How is hyperkalemic periodic paralysis treated?

Dichlorphenamide 50-100 mg BID is indicated for hyperkalemic periodic paralysis. Thiazide diuretics and carbonic anhydrase inhibitors are used as prophylaxis. Thiazide diuretics have few short-term side effects; they are tried as first-line treatment.

Is periodic paralysis fatal?

Thyrotoxic hypokalemic periodic paralysis is a rare but potentially fatal emergency: case report and literature review. Bol Asoc Med P R.

How do you treat Hyperkalemic periodic paralysis?

Is there a cure for periodic paralysis?

The main treatment for PPP is to avoid anything that triggers the attacks. You might have to make some changes to your or your child’s diet or exercise routine. But medicines can also help control the balance of potassium in your body.

What is hypokalemia disease?

Hypokalemia is a metabolic imbalance characterized by extremely low potassium levels in the blood. It is a symptom of another disease or condition, or a side effect of diuretic drugs.

How rare is Hyperkalemic periodic paralysis?

Hyperkalemic periodic paralysis affects an estimated 1 in 200,000 people.

What is the treatment for periodic paralysis?

Thyrotoxic periodic paralysis. Potassium supplementation, dichlorphenamide, propranolol, and spironolactone may be helpful during the attacks as well as for prophylaxis. Dichlorphenamide 50-100 mg BID or propranolol in doses of 20-40 mg twice a day may be sufficient to control recurrent attacks of periodic paralysis.

How is periodic paralysis diagnosed?

Periodic paralysis syndrome is diagnosed by family history, characteristic symptoms, laboratory tests, muscle biopsies, muscle cooling and/or muscle exercise, and repetitive stimulation of the nerves electrically; and in some people, provocative testing.

What does hyperkalemic mean?

Hyperkalemia is a medical term to indicate that the level of potassium in the blood is too high. Depending on the level of potassium in the blood, this can be a medical emergency.

What are the different types of periodic paralysis?

4 Types of Paralysis Monoplegia. Often affecting one limb, monoplegia is paralysis limited to a single area of the body. Hemiplegia. Similar to monoplegia, hemiplegia frequently affects limbs on one side of the body. Paraplegia. Paraplegia is paralysis of the legs and lower body. Quadriplegia.

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