Why is ibuprofen slightly soluble in water?

Ibuprofen has a polar end, the carboxylic acid group, which can act both as a hydrogen donor and a hydrogen acceptor establishing moderate to strong interactions with other polar molecules. The other part of ibuprofen is non-polar.

What is the solubility of ibuprofen?

Ibuprofen is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of (±)-ibuprofen in these solvents is approximately 60, 50, and 45 mg/ml, respectively.

How long does ibuprofen take to dissolve?

In general, it typically takes approximately 30 minutes for most medications to dissolve. When a medication is coated in a special coating – which may help protect the drug from stomach acids – often times it may take longer for the therapeutic to reach the bloodstream.

Is ibuprofen soluble in hydrochloric acid?

Drug release was very low in this medium as ibuprofen is practically insoluble in 0.1N HCl (Table 1).

Why is ibuprofen given racemic?

Racemic ibuprofen, which contains equal quantities of R(-)-ibuprofen and S(+)-ibuprofen, has been used as an anti-inflammatory and analgesic agent for over 30 years. Although the S(+)-enantiomer is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor.

What is racemic ibuprofen soluble in?

Ibuprofen is practically insoluble in water, but very soluble in most organic solvents like ethanol (66.18 g/100 mL at 40 °C for 90\% EtOH), methanol, acetone and dichloromethane.

Is ibuprofen solubility in water?

Ibuprofen is a commonly used pain reliever. Its chemical properties include: Ibuprofen has a poor water solubility with less than 1 mg of ibuprofen dissolving in 1 ml water.

Does ibuprofen dissolve in water?

How is ibuprofen excreted?

The excretion of ibuprofen is rapid and complete. Ibuprofen’s elimination half-life is 1–2 h. Approximately 90\% of an ingested dose is excreted in the urine as metabolites or their conjugates, and 10\% is eliminated as free drug.

Where is ibuprofen excreted?

Ibuprofen is rapidly metabolized and eliminated in the urine thus, this via accounts for more than 90\% of the administered dose. It is completely eliminated in 24 hours after the last dose and almost all the administered dose goes through metabolism, representing about 99\% of the eliminated dose.

What is the formula for ibuprofen?

The chemical name for ibuprofen is (±)-2- (p-isobutylphenyl) propionic acid. The molecular weight of ibuprofen is 206.28. Its molecular formula is C 13 H 18 O 2 and it has the following structural formula:

Is ibuprofen polar or nonpolar?

Ibuprofen is relatively non-polar. This is because it has non-polar alkyl groups and a benzene ring that reduces the overall polarity of the molecule contributed by its carboxyl group. Therefore, ibuprofen is only slightly soluble in water, dissolving 21 milligrams only per liter of water at 25 degrees Celsius.

What are the interactions of ibuprofen?

Ibuprofen Drug Interactions. Some of the drugs that can potentially interact with ibuprofen include aspirin, lithium, and diuretics. Ibuprofen has also been known to interact with a number of herbal and nutritional supplements to increase your risk of bleeding. Certain drug interactions can increase your risk of stomach ulcers;

What are the chemical properties of ibuprofen?

Ibuprofen is a commonly used pain reliever. Its chemical properties include: Ibuprofen has a poor water solubility with less than 1 mg of ibuprofen dissolving in 1 ml water. It is more soluble in aqueous alcohol mixtures.