Why is it important for a chromatin to be condensed?

Abstract. Chromosome condensation is one of the major chromatin-remodeling events that occur during cell division. The changes in chromatin compaction and higher-order structure organization are essential requisites for ensuring a faithful transmission of the replicated genome to daughter cells.

Why is it important for the chromosomes to condense during mitosis?

Chromosomes condense before mitosis to allow them the ability to move smoothly, without becoming entangled and breaking. (So, they are conveniently packaged for cell division, in which the chromosomes must move to both poles of the cell.)

Why is it important for DNA to condense?

If the chromosomes do not line up properly, severe genetic abnormalities can occur, which can lead to death of the cell or cancer. Condensing the DNA into tightly packed chromosomes makes the process of chromosome alignment and separation during mitosis more efficient.

Why chromosomes are condensed Mcq?

Why are chromosomes condensed? Explanation: As the cells enter mitosis, there chromosomes become highly condensed so that they can be distributed to daughter cells.

Why is condensation necessary for cell division?

Mitotic chromosome condensation is an essential cellular function ensuring proper compaction and segregation of sister chromatids during cell division. Being at the intersection of several cell-cycle regulatory networks condensin is a promising therapeutic target for control over cell proliferation.

How does histone condense chromatin?

Chromatin condensation is the result of long strands of DNA coiling around an octamer of regulatory proteins known as histones: H2A, H2B, H3, and H4 [5]. These coiled structures of DNA and histones are referred to as nucleosomes.

Why chromosomes are condensed?

Chromatin, a substance that contains genetic material such as DNA, is normally found in a loose bundle inside a cell’s nucleus. During the prophase of mitosis, the chromatin in a cell compacts to form condensed chromosomes; this condensation is required in order for the cell to divide properly.

What is the function of spindle Fibres?

Spindle fibers form a protein structure that divides the genetic material in a cell. The spindle is necessary to equally divide the chromosomes in a parental cell into two daughter cells during both types of nuclear division: mitosis and meiosis.

What happens when the chromatin condenses?

During prophase, the complex of DNA and proteins contained in the nucleus, known as chromatin, condenses. The chromatin coils and becomes increasingly compact, resulting in the formation of visible chromosomes. Chromosomes are made of a single piece of DNA that is highly organized.

Why do chromatin Fibres Organise themselves into chromosomes?

When do chromatin fibres organize themselves into chromosomes? Chromatin fibres contract and condense and get formed into chromosomes when the time comes for cell division. The condensation of chromatin fibres into sister chromatids is known to begin to occur in the prophase , gradually moving on to the metaphase.

Why does methylation condense chromatin?

The prevailing opinion suggests that DNA methylation provides preferential binding sites for specific proteins, i.e., MeCP2, which helps to recruit other nucleosome-binding proteins and synergistically promotes the compaction of methylated chromatin (10,11).