Table of Contents
- 1 Can thalassemia develop in adulthood?
- 2 What is the hemoglobin level for thalassemia?
- 3 Can thalassemia go undetected?
- 4 What conditions can be diagnosed with hemoglobin electrophoresis?
- 5 Can someone with thalassemia minor donate blood?
- 6 What is the most common type of hemoglobin in adults?
- 7 Does α-thalassemia affect HBA 1C measurement?
- 8 What is thalassemia (alpha or beta hemoglobin)?
Can thalassemia develop in adulthood?
It is only thalassemia minor/trait which may be diagnosed in adulthood and does not carry a great clinical significance being asymptomatic in majority of individuals.
What is the hemoglobin level for thalassemia?
Thalassemia major is characterized by reduced Hb level (<7 g/dl), mean corpuscolar volume (MCV) > 50 < 70 fl and mean corpuscolar Hb (MCH) > 12< 20 pg. Thalassemia intermedia is characterized by Hb level between 7 and 10 g/dl, MCV between 50 and 80 fl and MCH between 16 and 24 pg.
Is thalassemia related to hemoglobin?
Thalassemia (thal-uh-SEE-me-uh) is an inherited blood disorder that causes your body to have less hemoglobin than normal. Hemoglobin enables red blood cells to carry oxygen. Thalassemia can cause anemia, leaving you fatigued. If you have mild thalassemia, you might not need treatment.
Which hemoglobin is increased with thalassemia?
The distinguishing finding in beta thalassemia is a hemoglobin electrophoresis with the finding of elevated Hgb A2 and F. Both will be increased in beta thalassemia trait without iron deficiency, and will be normal or decreased in alpha thalassemia and isolated iron deficiency anemia.
Can thalassemia go undetected?
Many individuals with beta thalassemia minor go through life never knowing they carry an altered gene for the disorder. A beta thalassemia major diagnosis is usually made during the first two years of life and individuals require regular blood transfusions and lifelong medical care to survive.
What conditions can be diagnosed with hemoglobin electrophoresis?
A hemoglobin electrophoresis will indicate if there are any abnormal types of hemoglobin caused by genetic disorders….2. To diagnose blood disorders: Your doctor may have you do a hemoglobin electrophoresis test if you’re showing symptoms of anemia.
- sickle cell anemia.
- polycythemia vera.
What does a CBC look like with thalassemia?
A complete blood count (CBC), which includes measures of hemoglobin and the quantity (and size) of red blood cells. People with thalassemias have fewer healthy red blood cells and less hemoglobin than normal; those with alpha or beta thalassemia trait may have smaller-than-normal red blood cells.
Can thalassemia cause erectile dysfunction?
In patients with thalassemia major or transfusion-dependent thalassemia, ED is a possible complication predominantly due to iron overload as a result of recurrent blood transfusion leading to hypogonadism.
Can someone with thalassemia minor donate blood?
You must not donate blood if you have had babesiosis. You will be permanently deferred. If you have G6PD (Glucose-6-Phosphate Dehydrogenase Deficiency) or Thalassemia (minor), you can donate blood if you meet the haemoglobin requirement.
What is the most common type of hemoglobin in adults?
The most common types of normal hemoglobin are:
- Hemoglobin A. This is the most common type of hemoglobin found normally in adults.
- Hemoglobin F (fetal hemoglobin). This type is normally found in fetuses and newborn babies.
- Hemoglobin A2. This is a normal type of hemoglobin found in small amounts in adults.
Can thalassemia skip a generation?
Thalassemia is an inherited condition. The genes received from one’s parents before birth determine whether a person will have thalassemia. Thalassemia cannot be caught or passed on to another person.
What is the inheritance pattern of thalassemia?
A person is either a biological male or female. The inheritance pattern is complicated in patients with thalassemia because two sets of genes on different chromosomes cooperate to produce hemoglobin. A defect anywhere in this complex can produce thalassemia.
Does α-thalassemia affect HBA 1C measurement?
Effects of α-Thalassemia on HbA 1c Measurement In this study, HbA1c values in samples from individuals with two or three functional α-genes basically reflected the normal mean blood glucose level, while those in samples from individuals with one functional α-gene did not.
What is thalassemia (alpha or beta hemoglobin)?
Hemoglobin, which carries oxygen to all cells in the body, is made of two different parts, called alpha and beta. When thalassemia is called “alpha” or “beta,” this refers to the part of hemoglobin that isn’t being made. If either the alpha or beta part is not made, there aren’t enough building blocks to make normal amounts of hemoglobin.
What are the chances of having a child with thalassemia?
A one-in-four chance also exists that a child will inherit two thalassemia genes, and have a severe form of thalassemia (thalassemia major or thalassemia intermedia). A one-in-two chance exists that the child will inherit a normal gene from one parent and a thalassemia gene from the other.